Tumor-derived vascular endothelial growth factor (VEGF)-a facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway.

@article{Liu2011TumorderivedVE,
  title={Tumor-derived vascular endothelial growth factor (VEGF)-a facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway.},
  author={Wenbo Liu and Jiying Xu and Mingming Wang and Qiangxiu Wang and Yuli Bi and Mingyong Han},
  journal={International journal of oncology},
  year={2011},
  volume={39 5},
  pages={1213-20}
}
Vascular endothelial growth factor (VEGF) and its receptors are involved in carcinogenesis, invasion and tumor angiogenesis, but the underlying mechanism by which VEGF promotes tumor metastasis is poorly understood. In this study, we show that in cancer patients high expression of VEGF is correlated with metastasis, and anti-VEGF treatment (bevacizumab) has clinical effects on tumor metastasis. Two human lung carcinoma cell lines (A549 and SPCA1 cells) with distinct VEGF expression were… CONTINUE READING
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Metastasis mechanisms.

Biochimica et biophysica acta • 2009

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