Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model

Abstract

High-mobility group box 1 (HMGB1) is involved in the tumor-associated activation of regulatory T cells (Treg), but the mechanisms remain unknown. In a mouse tumor model, silencing HMGB1 in tumor cells or inhibiting tumor-derived HMGB1 not only dampened the capacity of tumor cells to produce thymic stromal lymphopoietin (TSLP), but also aborted the tumor… (More)
DOI: 10.1007/s00262-017-2087-7

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@article{Zhang2017TumorderivedHG, title={Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model}, author={Yi Zhang and Zuqiang Liu and Xingxing Hao and Ang Li and Jiying Zhang and Cara D. Carey and Louis D. Falo and Zhaoyang You}, journal={Cancer Immunology, Immunotherapy}, year={2017}, pages={1-14} }