Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

@inproceedings{Ye2014TumorderivedEP,
  title={Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma},
  author={Shu-biao Ye and Ze-Lei Li and Dong-hua Luo and Bi-jun Huang and Yu-Suan Chen and Xiao-shi Zhang and Jun Cui and Yi-xin Zeng and Jiang Li},
  booktitle={Oncotarget},
  year={2014}
}
Tumor-derived exosomes contain biologically active proteins and messenger and microRNAs (miRNAs). These particles serve as vehicles of intercellular communication and are emerging mediators of tumorigenesis and immune escape. Here, we isolated 30-100 nm exosomes from the serum of patients with nasopharyngeal carcinoma (NPC) or the supernatant of TW03 cells. Increased circulating exosome concentrations were correlated with advanced lymphoid node stage and poor prognosis in NPC patients (P< 0.05… CONTINUE READING

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