Tumor-derived exosomes and microvesicles in head and neck cancer: implications for tumor biology and biomarker discovery.

@article{Principe2013TumorderivedEA,
  title={Tumor-derived exosomes and microvesicles in head and neck cancer: implications for tumor biology and biomarker discovery.},
  author={Simona Principe and Angela Bik-Yu Hui and Jeff P. Bruce and Ankit Sinha and Fei-Fei Liu and Thomas Kislinger},
  journal={Proteomics},
  year={2013},
  volume={13 10-11},
  pages={1608-23}
}
Exosomes and microvesicles (MVs) are nanometer-sized, membranous vesicles secreted from many cell types into their surrounding extracellular space and into body fluids. These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infected cancer cells, regulate their micro-environment via the horizontal transfer of bioactive molecules: proteins, lipids, and nucleic acids (DNA, mRNA, micro-RNAs; oncogenic cargo hence often referred… CONTINUE READING

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