Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cell.

@article{Monti2004TumorderivedMM,
  title={Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cell.},
  author={Paolo Monti and Biagio Eugenio Leone and Alessandro Zerbi and Gianpaolo Balzano and Silvia Cainarca and Valeria Sordi and Marina Pontillo and Alessia Mercalli and Valerio Di Carlo and Paola Allavena and Lorenzo Piemonti},
  journal={Journal of immunology},
  year={2004},
  volume={172 12},
  pages={7341-9}
}
Dendritic cells (DC) initiate immunity by the activation of naive T cells and control immunity through their ability to induce unresponsiveness of lymphocytes by mechanisms that include deletion and induction of regulatory cells. An inadequate presentation to T cells by tumor-induced "regulatory" DC, among several mechanisms, can explain tolerance to tumor-associated Ags. In this study, we show that tumor-derived mucin profoundly affects the cytokine repertoire of monocyte-derived DC and switch… CONTINUE READING

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