Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence.

@article{Ye2013TumorderivedR,
  title={Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence.},
  author={Jian Ye and Chunling Ma and Eddy C Hsueh and Christopher S. Eickhoff and Yanping Zhang and Mark A Varvares and Daniel F. Hoft and Guangyong Peng},
  journal={Journal of immunology},
  year={2013},
  volume={190 5},
  pages={
          2403-14
        }
}
Fundamentally understanding the suppressive mechanisms used by different subsets of tumor-infiltrating regulatory T (Treg) cells is critical for the development of effective strategies for antitumor immunotherapy. γδ Treg cells have recently been identified in human diseases including cancer. However, the suppressive mechanisms and functional regulations of this new subset of unconventional Treg cells are largely unknown. In the current studies, we explored the suppressive mechanism(s) used by… CONTINUE READING

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