Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity.

@article{Zeng2003TumorderivedCC,
  title={Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity.},
  author={Yi Zeng and Hanping Feng and Michael W Graner and Emmanuel Katsanis},
  journal={Blood},
  year={2003},
  volume={101 11},
  pages={
          4485-91
        }
}
We have utilized a free-solution isoelectric focusing technique (FS-IEF) to obtain chaperone-rich cell lysate (CRCL) fractions from clarified tumor homogenates and have previously reported on their vaccinating potential. To better understand the underlying mechanisms as well as to improve on the immunizing efficacy of tumor-derived chaperone complexes, in the present study we examined the effects of CRCL-loaded dendritic cells (DCs) against 12B1, an aggressive bcr-abl+ murine leukemia tumor. We… CONTINUE READING

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