Tumor dependence on the EGFR signaling pathway expressed by the p-EGFR:p-AKT ratio predicts erlotinib sensitivity in human non-small cell lung cancer (NSCLC) cells expressing wild-type EGFR gene.


INTRODUCTION This study was undertaken to identify molecular determinants of tumor dependency on the epidermal growth factor receptor (EGFR) signaling pathway for predicting clinical benefit from erlotinib monotherapy in non-small cell lung cancer (NSCLC) patients with tumors expressing wild-type EGFR gene. METHODS The effect of erlotinib on the total and… (More)
DOI: 10.1097/JTO.0b013e3181753b24