Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.

@article{Sharma2003TumorC2,
  title={Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.},
  author={Sherven P Sharma and Marina Stolina and Seok-Chul Yang and Felicita E. Baratelli and Jeff F Lin and Kimberly Atianzar and Jie Luo and Li Xin Zhu and Ying Q. Lin and Min Huang and Mariam M. Dohadwala and Raj Kumar Batra and Steven Dubinett},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 3},
  pages={
          961-8
        }
}
Dendritic cells (DCs) serve as professional antigen-presenting cells and are pivotal in the host immune response to tumor antigens. To define the pathways limiting DC function in the tumor microenvironment, we assessed the impact of tumor cyclooxygenase (COX)-2 expression on DC activities. Bone marrow-derived DCs were cultured in either tumor supernatant (TSN) or TSN from COX-2-inhibited tumors. After culture, DCs were pulsed with tumor-specific peptides, and their ability to generate antitumor… CONTINUE READING

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