Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

@article{Senger1983TumorCS,
  title={Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.},
  author={Donald R. Senger and Stephen J. Galli and Ann M. Dvorak and Carole A. Perruzzi and Veronica Harvey and Harold F. Dvorak},
  journal={Science},
  year={1983},
  volume={219 4587},
  pages={983-5}
}
Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors. 
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