Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia.

@article{Silva1990TumorCA,
  title={Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia.},
  author={Jos{\'e} Leal da Silva and Catherine Lacombe and Patrick Bruneval and Nicole Casadevall and Michel Leporrier and Jean Philippe Camilleri and Jean Bari{\'e}ty and Pierre E. Tambourin and B. Varet},
  journal={Blood},
  year={1990},
  volume={75 3},
  pages={577-82}
}
One to five percent of human renal cell carcinomas are associated with polycythemia. It is generally assumed that polycythemia results from the secretion of erythropoietin (Epo) by the malignant cells. However, there is no direct proof supporting this hypothesis. Three patients with typical renal adenocarcinoma and polycythemia were studied. All three exhibited high Epo serum levels as measured by radioimmunoassay (RIA). A strong Epo signal was observed on Northern blot analysis of total RNA… CONTINUE READING
30 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Peritubular capillary cells are the site of erythropoietin synthesis in the murine hypoxic kidney

  • C Lacombe, JL DaSilva, +7 authors P Tambourin
  • J Clin Invest
  • 1988

Clinical significance of erythropoietin levels in renal carcinoma

  • UO Nseyo, PD Willams, GP Murphy
  • Urology
  • 1986

Similar Papers

Loading similar papers…