Tumor cells are protected from NK-cell-mediated lysis by adhesion to endothelial cells.

@article{Kaminski1988TumorCA,
  title={Tumor cells are protected from NK-cell-mediated lysis by adhesion to endothelial cells.},
  author={Mark Kaminski and Robert D. Auerbach},
  journal={International journal of cancer},
  year={1988},
  volume={41 6},
  pages={847-9}
}
We have examined the effect of various cell monolayers on the ability of mouse spleen cells to lyse tumor cell targets (natural cytotoxicity reaction). Natural killer (NK) cell activity was reduced by as much as 75% depending on the cell substrate, with the greatest protection afforded by endothelial cells. Cell adhesion to the underlying cell monolayer was… CONTINUE READING