Tumor cell specific dark cytotoxicity of light-exposed merocyanine 540: implications for systemic therapy without light.

@article{Gulliya1990TumorCS,
  title={Tumor cell specific dark cytotoxicity of light-exposed merocyanine 540: implications for systemic therapy without light.},
  author={Kirpal S. Gulliya and Shazib Pervaiz and Robert M. Dowben and James L. Matthews},
  journal={Photochemistry and photobiology},
  year={1990},
  volume={52 4},
  pages={831-8}
}
Merocyanine 540 (MC540) was activated by exposure to 514 nm laser light. The light-exposed MC540 was then mixed (in the dark) with tumor cells and normal cells to determine the antiproliferative activity. Treatment with light-exposed MC540 resulted in 70-90% tumor cell kill from different cell lines, while 85% of the normal human mononuclear cells and 41% of the granulocyte-macrophage colony forming cells (CFU-GM) survived the treatment. The observed cytotoxicity of light-exposed MC540 to the… CONTINUE READING