Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

  title={Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.},
  author={Mikhail A Nikiforov and Marybeth Riblett and Wen-hua Tang and Vladimir Gratchouck and Dazhong Zhuang and Yolanda Blanco Fern{\'a}ndez and M. H. Verhaegen and Sooryanarayana Varambally and Arul M. Chinnaiyan and Andrzej J. Jakubowiak and Mar{\'i}a S Soengas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 49},
The proteasome controls a plethora of survival factors in all mammalian cells analyzed to date. Therefore, it is puzzling that proteasome inhibitors such as bortezomib can display a preferential toxicity toward malignant cells. In fact, proteasome inhibitors have the salient feature of promoting a dramatic induction of the proapoptotic protein NOXA in a tumor cell-restricted manner. However, the molecular determinants that control this specific regulation of NOXA are unknown. Here, we show that… CONTINUE READING
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