Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts.

@article{Shieh2011TumorCI,
  title={Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts.},
  author={Adrian C. Shieh and Hallie A Rozansky and Boris Hinz and Melody A Swartz},
  journal={Cancer research},
  year={2011},
  volume={71 3},
  pages={790-800}
}
Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how interstitial fluid flow affects fibroblast-tumor cell interactions. Using a 3-dimensional invasion assay and MDA-MB-435S cells cocultured with dermal fibroblasts in a collagen matrix, we showed a synergistic enhancement of tumor cell invasion… CONTINUE READING
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