Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.

@article{Bruner1990TumorCI,
  title={Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.},
  author={T Br{\"a}uner and Dieter F. H{\"u}lser},
  journal={Invasion & metastasis},
  year={1990},
  volume={10 1},
  pages={31-48}
}
The invasive behavior of five tumor cell lines was investigated with an in vitro invasion assay developed by Mareel et al. Spheroids of all 5 cell lines readily attached to precultured heart fragments (PHF), resulting in confronting pairs. Tumor cells (BICR/M1Rk, C6, and EMT6/Ro) which communicated with the host tissue via gap junctions, rapidly invaded the… CONTINUE READING