Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide.

@article{Brandley1989TumorCH,
  title={Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide.},
  author={Brian K. Brandley and Ronald L. Schnaar},
  journal={Developmental biology},
  year={1989},
  volume={135 1},
  pages={74-86}
}
The movement of cells up an adhesive substratum gradient has been proposed as a mechanism for directing cell migration during development and metastasis. Critical evaluation of this hypothesis (haptotaxis) benefits from the use of quantifiable, stable substratum gradients of biologically relevant adhesion molecules. We report covalent derivatization of polyacrylamide surfaces with quantifiable gradients of a nonapeptide containing the adhesive Arg-Gly-Asp sequence. Cell migration was studied by… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…