Tumor cell embryonality and the ploidy number 32n: Is it a developmental checkpoint?

  title={Tumor cell embryonality and the ploidy number 32n: Is it a developmental checkpoint?},
  author={J. Erenpreisa and M. Cragg and A. P. Anisimov and T. Illidge},
  journal={Cell Cycle},
  pages={1873 - 1874}
In recent years, several independent laboratories have demonstrated the ability of p53 function-deficient human tumor cells to undergo a process of reversible polyploidy to provide clonogenic re-growth after genotoxic (DNA-damaging and spindle-disturbing) treatment, f.ex. In this letter we wish to attract attention to the apparent limits of this polyploidy, namely the generation of 16–32n progeny. The question is why does this limit exist? Does it represent a fundamental limit of polyploidy… Expand
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Immediate Publication; DOI: 10.1042/CBI20100762
  • Cell Biol Int
  • 2011