Tumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile.

@article{Ribeiro2012TumorCP,
  title={Tumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile.},
  author={Ricardo J. T. Ribeiro and C{\'a}tia P. D. Monteiro and V Cunha and Andreia Sofia Azevedo and Maria Jos{\'e} Oliveira and Ros{\'a}rio Monteiro and Avelino M. Fraga and Paulo Pr{\'i}ncipe and Carlos Trece{\~n}o Lobato and Francisco Pereira Lobo and Ant{\'o}nio Morais and V{\'i}tor Silva and Jos{\'e} Sanches-Magalh{\~a}es and Jorge Luiz Barcelos Oliveira and Jo{\~a}o Tiago Guimar{\~a}es and Carlos Silva Lopes and Rui Medeiros},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2012},
  volume={29 1-2},
  pages={233-40}
}
BACKGROUND/AIMS The microenvironment produces important factors that are crucial to prostate cancer (PCa) progression. However, the extent to which the cancer cells stimulate periprostatic adipose tissue (PPAT) to produce these proteins is largely unknown. Our purpose was to determine whether PCa cell-derived factors influence PPAT metabolic activity. METHODS Primary cultures of human PPAT samples from PCa patients (adipose tissue organotypic explants and primary stromal vascular fraction… CONTINUE READING