Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1.

@article{Zeidler2000TumorCP,
  title={Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1.},
  author={Reinhard Zeidler and Mikl{\'o}s Csan{\'a}dy and Olivier Gires and S. W. Lang and Baerbel Schmitt and Barbara Wollenberg},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 5},
  pages={661-8}
}
The cyclooxygenases (COX)-1 and COX-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Whereas COX-1 is expressed ubiquitously, COX-2 is an immediate-early gene often associated with malignant transformation, and a role for the COX enzymes in tumor initiation and promotion is discussed. Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and indomethacin that block COX-1 and -2 have been shown to have beneficial effects for tumor patients… CONTINUE READING

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