Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.

@article{Endo2012TumorCA,
  title={Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.},
  author={Motoyoshi Endo and Masahiro Nakano and Tsuyoshi Kadomatsu and Shigetomo Fukuhara and Hiroaki Kuroda and Shuji Mikami and Tai Hato and Jun Aoi and Haruki Horiguchi and Keishi Miyata and Haruki Odagiri and Tetsuro Masuda and Masahiko Harada and Hirotoshi Horio and Tsunekazu Hishima and Hiroaki Nomori and Takaaki Ito and Yutaka Yamamoto and Takashi Minami and Seiji Okada and Takashi Takahashi and Naoki Mochizuki and Hirotaka Iwase and Yuichi Oike},
  journal={Cancer research},
  year={2012},
  volume={72 7},
  pages={
          1784-94
        }
}
Strategies to inhibit metastasis have been mainly unsuccessful in part due to insufficient mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like protein 2 (ANGPTL2) in metastatic progression. In mice, Angptl2 has been implicated in inflammatory carcinogenesis but it has not been studied in human tumors. In patients with lung cancer, elevated levels of ANGPTL2 expression in tumor cells within the primary tumor were associated with a reduction in the… 
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Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis
TLDR
It is shown that stroma-derived ANGPTL2 can activate the myeloid immune response and drove generation of immunostimulatory macrophages via the NF-κB pathway, accelerating CD4 + T helper 1 (Th1) cell activation.
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M 2 tumor-associated macrophages
TLDR
It is determined that Angptl2 promoted the M2 polarization of TAMs and enhanced NSCLC progression, and might be an effective strategy for reprogramming TAM polarization in NSCLCs.
Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer
TLDR
The current knowledge about the functions of the ANGPTL proteins in angiogenesis, cancer progression and metastasis is outlined, and the most recent evidences sustaining their role as prognostic or predictive biomarkers for cancer therapy are discussed.
The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin α5β1, p38 MAPK, and Matrix Metalloproteinases
TLDR
ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin α5β1, p38 mitogen-activated protein kinase, and matrix metalloproteinases.
Tumor cell‐derived angiopoietin‐like protein 2 establishes a preference for glycolytic metabolism in lung cancer cells
TLDR
Evidence is reported supporting a role for tumor cell‐derived ANGPTL2 in establishing a preference for glycolytic metabolism in lung cancer cells by activating TGF‐β‐ZEB1‐GLUT3 signaling.
Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase–phosphoinositide 3-kinase-dependent anti-apoptotic signaling
TLDR
Investigating whether ANGPTL2 expression altered survival of human colorectal cancer cell lines treated with antineoplastic drugs suggested that attenuating Angiopoietin‐like protein 2 signaling in tumor cells may block tumor cell resistance to antineopolastic therapies.
Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer.
TLDR
Evidence supporting ANGPTL2 and miR-25 as diagnostic or therapeutic targets for CRC is provided, suggesting for the first time that the abnormal upregulation of Angiopoietin-like protein-2 in CRC is associated with miR -25 downregulation.
Angiopoietin-Like Protein 2 Acts as a Novel Biomarker for Diagnosis and Prognosis in Patients with Esophageal Cancer
TLDR
No significant association between serum Angiopoietin-like protein 2 levels and clinicopathological findings was observed in patients with EC, and novel evidence for the clinical significance of ANGPTL2 as a biomarker was demonstrated.
An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis
TLDR
Findings showed that the autocrine signaling of Angiopoietin-like Protein (ANGPTL)2 and its receptor LILRB2 plays key roles in sustaining EMT and the early metastatic behavior of cells in pancreatic preneoplastic lesions supporting the potential role of ANGPTL2 for early detection, metastasis prevention, and treatment in PDAC.
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