Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.

  title={Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.},
  author={Motoyoshi Endo and Masahiro Nakano and Tsuyoshi Kadomatsu and Shigetomo Fukuhara and Hiroaki Kuroda and Shuji Mikami and Tai Hato and Jun Aoi and Haruki Horiguchi and Keishi Miyata and Haruki Odagiri and Tetsuro Masuda and Masahiko Harada and Hirotoshi Horio and Tsunekazu Hishima and Hiroaki Nomori and Takaaki Ito and Yutaka Yamamoto and Takashi Minami and Seiji Okada and Takashi Takahashi and Naoki Mochizuki and Hirotaka Iwase and Yuichi Oike},
  journal={Cancer research},
  volume={72 7},
Strategies to inhibit metastasis have been mainly unsuccessful in part due to insufficient mechanistic understanding. Here, we report evidence of critical role for the angiopoietin-like protein 2 (ANGPTL2) in metastatic progression. In mice, Angptl2 has been implicated in inflammatory carcinogenesis but it has not been studied in human tumors. In patients with lung cancer, elevated levels of ANGPTL2 expression in tumor cells within the primary tumor were associated with a reduction in the… CONTINUE READING


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