Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity.

@article{Aymeric2010TumorCD,
  title={Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity.},
  author={Laetitia Aymeric and Lionel Apetoh and François Ghiringhelli and Antoine Tesni{\`e}re and Isabelle Christine V. S. Martins and Guido Kroemer and Mark J Smyth and Laurence Zitvogel},
  journal={Cancer research},
  year={2010},
  volume={70 3},
  pages={855-8}
}
By destroying tumor cells, conventional anticancer therapies may stimulate the host immune system to eliminate residual disease. Anthracyclines, oxaliplatin, and ionizing irradiation activate a type of tumor cell death that elicits efficient anticancer immune responses depending on interferon gamma (IFNgamma) and the IFNgamma receptor. Thus, dying tumor cells emit danger signals that are perceived by dendritic cells (DC), which link innate and cognate immune responses. Recently, we observed… CONTINUE READING
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