Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor.

@article{Kuettner1977TumorCC,
  title={Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor.},
  author={Klaus E. Kuettner and L. W. Soble and R. L. Croxen and B Marczynska and J Hiti and Elvin Harper},
  journal={Science},
  year={1977},
  volume={196 4290},
  pages={653-4}
}
Human osteosarcoma and mammary carcinoma cells were cultured separately in a medium supplemented with fetal calf serum, until they were confluent. The medium was then replaced by serum-free medium supplemented with heparin. Both cell cultures secreted collagenase, and this activity was inhibited by a cartilage-derived protein of low molecular weight. Since cartilage is rarely invaded by neoplasms, the presence of this inhibitor may play an important role in the regulation of tumor invasion. 
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