Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.

@article{Sorscher1994TumorCB,
  title={Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.},
  author={Eric Sorscher and Sheng-bin Peng and Zsuzsa Bebők and Paula W. Allan and L. Lee Bennett and William B. Parker},
  journal={Gene therapy},
  year={1994},
  volume={1 4},
  pages={233-8}
}
Inefficiency of gene delivery, together with inadequate bystander killing, represent two major hurdles in the development of a toxin-mediated gene therapy for human malignancy. The product of the Escherischia coli DeoD gene (purine nucleoside phosphorylase, PNP) differs from the mammalian enzyme in its substrate specificity and is capable of catalyzing the… CONTINUE READING