Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation.

@article{Mohamad2002TumorCA,
  title={Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation.},
  author={Saharuddin Bin Mohamad and Hideko Nagasawa and Yoshihiro Uto and Hitoshi Hori},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2002},
  volume={132 1},
  pages={1-8}
}
Alpha-N-acetyl galactosaminidase (alpha-NaGalase) has been reported to accumulate in serum of cancer patients and be responsible for deglycosylation of Gc protein, which is a precursor of GcMAF-mediated macrophage activation cascade, finally leading to immunosuppression in advanced cancer patients. We studied the biochemical characterization of alpha-NaGalase from several human tumor cell lines. We also examined its effect on the potency of GcMAF to activate mouse peritoneal macrophage to… CONTINUE READING
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Cloning of malignant cell-derived serum alpha-Nacetylgalactosaminidase that plays a role in immunosuppression

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  • Proc. Am. Assoc. Cancer. Res
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