Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer.

@article{Shinto2006TumorBS,
  title={Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer.},
  author={Eiji Shinto and Kristi Baker and Hitoshi Tsuda and Hidetaka Mochizuki and Hideki Ueno and Osamu Matsubara and William D Foulkes and Jeremy R. Jass},
  journal={Diseases of the colon and rectum},
  year={2006},
  volume={49 8},
  pages={1193-202}
}
PURPOSE Tumor budding at the invasive margin of colorectal cancer is an important adverse prognostic factor. The subset of colorectal cancer that is deficient in DNA mismatch repair has been associated with a good prognosis. It is hypothesized that tumor budding in this subset may lack biologic aggressiveness because it is not associated with aberrant expression of the independent prognostic factor, laminin-5 gamma 2. METHODS Eighty colorectal cancers with high-grade tumor budding were… CONTINUE READING

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