Tumor blood flow: the principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromilieu of human tumor xenografts in vivo.

@article{Kallinowski1989TumorBF,
  title={Tumor blood flow: the principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromilieu of human tumor xenografts in vivo.},
  author={F. Kallinowski and Karleheinz Schlenger and M Kloes and M. Stohrer and Peter Vaupel},
  journal={International journal of cancer},
  year={1989},
  volume={44 2},
  pages={266-72}
}
We have investigated therapeutically relevant pathophysiological parameters of human breast and lung cancer xenografts in nude rats. All lung cancers and one breast cancer exhibited rapid growth and high blood flow values paralleled by high metabolic rates. The tissue of these tumors was well oxygenated up to very advanced growth stages. Xenografts from… CONTINUE READING