Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs.

@article{Shaul2016TumorassociatedND,
  title={Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs.},
  author={Merav E Shaul and Liran Levy and Jing Sun and Inbal Mishalian and Sunil Singhal and Veena Kapoor and W. C. Horng and Gil Fridlender and Steven M. Albelda and Zvi Gregory Fridlender},
  journal={Oncoimmunology},
  year={2016},
  volume={5 11},
  pages={e1232221}
}
It is becoming increasingly clear that tumor-associated neutrophils (TANs) play an important role in cancer biology, through direct impact on tumor growth and by recruitment of other cells types into the tumor. The function of neutrophils in cancer has been the subject of seemingly contradicting reports, pointing toward a dual role played by TANs in tumor progression. The existence of multiple neutrophil subsets, as well as phenotypic modulation of the neutrophils by various factors in the… CONTINUE READING
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