Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.

@article{Fan2014TumorassociatedMP,
  title={Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.},
  author={Qing-Min Fan and Yingying Jing and Guo-feng Yu and Xing-Rui Kou and Fei Ye and Lu Gao and Rong Li and Qiu-dong Zhao and Yang Yang and Zheng-Hua Lu and Lixin Wei},
  journal={Cancer letters},
  year={2014},
  volume={352 2},
  pages={160-8}
}
Tumor-associated macrophages (TAMs), a crucial component of immune cells infiltrated in tumor microenvironment, have been found to be associated with progression and metastasis of hepatocellular carcinoma (HCC). In this study, we aimed to clarify the mechanism underlying the crosstalk between TAMs and cancer stem cells (CSCs) in HCC. Mouse macrophage cell line RAW264.7 cells were used to investigate the effects of TAMs on mouse hepatoma cell line Hepa1-6 cells in vivo and vitro. A total of 90… CONTINUE READING