Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.

@article{Schoppmann2002TumorassociatedME,
  title={Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.},
  author={Sebastian F. Schoppmann and Peter Birner and Johannes St{\"o}ckl and Romana Kalt and Robert G. Ullrich and Carola Caucig and Ernst Kriehuber and K. Zsuzsanna Nagy and Kari Alitalo and Dontscho Kerjaschki},
  journal={The American journal of pathology},
  year={2002},
  volume={161 3},
  pages={
          947-56
        }
}
Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells and predicts poor clinical prognosis. Lymphatic vessels generally arise within the peritumoral stroma, although the lymphangiopoietic vascular endothelial growth factors (VEGF)-C and -D are produced by tumor cells. In a carefully selected collection of human cervical cancers (stage pT1b1) we demonstrate by quantitative immunohistochemistry and in situ hybridization that density of lymphatic… CONTINUE READING

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