Tumor associated macrophages and neutrophils in tumor progression

@article{Galdiero2013TumorAM,
  title={Tumor associated macrophages and neutrophils in tumor progression},
  author={M. R. Galdiero and C. Garlanda and S. Jaillon and G. Marone and A. Mantovani},
  journal={Journal of Cellular Physiology},
  year={2013},
  volume={228}
}
  • M. R. Galdiero, C. Garlanda, +2 authors A. Mantovani
  • Published 2013
  • Biology, Medicine
  • Journal of Cellular Physiology
  • Tumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte–macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a spectrum of activation states. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their… CONTINUE READING
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    References

    SHOWING 1-10 OF 160 REFERENCES
    Origins of tumor-associated macrophages and neutrophils
    • 414
    • PDF
    Macrophage plasticity and polarization: in vivo veritas.
    • 3,495
    • PDF
    Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
    • 243
    • PDF
    Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility
    • 292
    • PDF
    The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
    • 784
    • PDF
    Differential macrophage programming in the tumor microenvironment.
    • 593
    Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • 2,426
    Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • 576
    • PDF
    Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype1
    • 366
    • PDF
    Tumor-associated neutrophils: new targets for cancer therapy.
    • 494
    • PDF