Tumor associated macrophages and neutrophils in tumor progression

  title={Tumor associated macrophages and neutrophils in tumor progression},
  author={M. R. Galdiero and C. Garlanda and S. Jaillon and G. Marone and A. Mantovani},
  journal={Journal of Cellular Physiology},
  • M. R. Galdiero, C. Garlanda, +2 authors A. Mantovani
  • Published 2013
  • Biology, Medicine
  • Journal of Cellular Physiology
  • Tumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte–macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a spectrum of activation states. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their… CONTINUE READING
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