Tumor-associated macrophages: a molecular perspective.

  title={Tumor-associated macrophages: a molecular perspective.},
  author={Antonio Sica and Alessandra Saccani and Alberto Mantovani},
  journal={International immunopharmacology},
  volume={2 8},
The "macrophage balance hypothesis" was proposed in the early 1990s to depict the complex relationship that tumor-associated macrophages (TAM) have with the neoplastic cells of the tumor. TAM represent a prominent component of the mononuclear leukocyte population of solid tumors, which displays an ambivalent relationship with tumors. They originate in the circulation and are recruited to the tumor site by tumor-derived attractants such as chemokines and interact with the tumor cells and… CONTINUE READING

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