Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.

@article{Denkert2010TumorassociatedLA,
  title={Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.},
  author={Carsten Denkert and Sibylle Loibl and Aurelia Noske and Marc Roller and Berit M. M{\"u}ller and Martina Komor and Jan Budczies and Silvia Darb-Esfahani and Ralf Kronenwett and Claus Hanusch and Christian von T{\"o}rne and Wilko Weichert and K. A. Engels and Christine Solbach and Iris Schrader and Manfred Dietel and Gunter von Minckwitz},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 1},
  pages={105-13}
}
PURPOSE Preclinical data suggest a contribution of the immune system to chemotherapy response. In this study, we investigated the prespecified hypothesis that the presence of a lymphocytic infiltrate in cancer tissue predicts the response to neoadjuvant chemotherapy. METHODS We investigated intratumoral and stromal lymphocytes in a total of 1,058 pretherapeutic breast cancer core biopsies from two neoadjuvant anthracycline/taxane-based studies (GeparDuo, n = 218, training cohort; and GeparTrio… CONTINUE READING
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