Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?

@article{KunzSchughart2002TumorassociatedF,
  title={Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?},
  author={Leoni A. Kunz-Schughart and Ruth Knuechel},
  journal={Histology and histopathology},
  year={2002},
  volume={17 2},
  pages={599-621}
}
Phenotypic and functional characteristics of tumor associated fibroblasts (TAF) in contrast to normal fibroblasts are reviewed in this first synopsis (part I). Terms as tumor stroma, desmo-plasia, TAF, myofibroblast, and fetal-type fibroblast are defined, and experimental systems to study heterologous cell interactions are presented. While we only start to gather information on the genotype of TAF, a broad range of data deals with the expression profile of these cells, covering e.g. ECM and ECM… CONTINUE READING