Tumor-associated carbonic anhydrases and their clinical significance.

  title={Tumor-associated carbonic anhydrases and their clinical significance.},
  author={Silvia Pastorekov{\'a} and Seppo Parkkila and Jan Z{\'a}vada},
  journal={Advances in clinical chemistry},
Carbonic anhydrases (CAs) are physiologically important enzymes that catalyze a reversible conversion of carbon dioxide to bicarbonate and participate in ion transport and pH control. Two human isoenzymes, CA IX and CA XII, are overexpressed in cancer and contribute to tumor physiology. Particularly CA IX is confined to only few normal tissues but is ectopically induced in many tumor types mainly due to its strong transcriptional activation by hypoxia accomplished via HIF-1 transcription factor… CONTINUE READING