Tumor-associated antigen L6 and the invasion of human lung cancer cells.

  title={Tumor-associated antigen L6 and the invasion of human lung cancer cells.},
  author={Yu-Rong Kao and Jin-Yuan Shih and Wei-Chun Wen and Y Ko and B M Chen and Yi-Lin Chan and Yi-Wen Chu and Pan-Chyr Yang and C Wu and Steve R Roffler},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 7},
Metastasis is a coordinated process that depends on the interaction of cancer cells with the tumor microenvironment. Members of the transmembrane-4 superfamily (TM4SF) of surface proteins have been implicated in the regulation of cancer cell metastasis, and the expression of several TM4SF members on tumor cells is inversely correlated with patient prognosis. The tumor-associated antigen L6 (TAL6), a distant member of the TM4SF, is expressed on most epithelial cell carcinomas and is a target for… CONTINUE READING
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