Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice.

@article{Ryan2009TumorassociatedMG,
  title={Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice.},
  author={S. Ottridge Ryan and Anda M. Vlad and Kazi Islam and Jean Gari{\'e}py and Olivera Olja J Finn},
  journal={Biological chemistry},
  year={2009},
  volume={390 7},
  pages={
          611-8
        }
}
Human adenocarcinomas overexpress a hypoglycosylated, tumor-associated form of the mucin-like glycoprotein MUC1 containing abnormal mono- and disaccharide antigens, such as Tn, sialyl-Tn, and TF, as well as stretches of unglycosylated protein backbone in the variable number of tandem repeats (VNTR) region. Both peptide and glycopeptide epitopes generated from the VNTR are candidates for cancer vaccines and we performed experiments to evaluate their relative potential to elicit tumor-MUC1… CONTINUE READING

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Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat

M. A. Tarp, A. L. Sorensen, +4 authors H. Clausen
  • Glycobiology
  • 2007
VIEW 3 EXCERPTS