Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

@article{Dong2002TumorassociatedBP,
  title={Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion},
  author={Haidong Dong and Scott E. Strome and Diva R. Salom{\~a}o and Hideto Tamura and Fumiya Hirano and Dallas B. Flies and Patrick C. Roche and Jun Lu and Gefeng Zhu and Koji Tamada and Vanda A. Lennon and Esteban Celis and Lieping Chen},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={793-800}
}
B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of… CONTINUE READING
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B 7 - H 1 costimulation preferentially enhances CD 28 - independent T - helper cell function

  • H. Tamura
  • Blood
  • 2001

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