Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium.

@article{Griffioen1996TumorAI,
  title={Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium.},
  author={Arjan W Griffioen and Cora A. Damen and Geert H. Blijham and Gerard Groenewegen},
  journal={Blood},
  year={1996},
  volume={88 2},
  pages={667-73}
}
We previously showed that endothelial cells (EC) from the vasculature of human solid tumors have a decreased expression of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 as compared with normal tissue EC. This effect is explained by EC exposure to angiogenic factors. It is known that upregulation of endothelial adhesion molecules (EAM) is a sign of EC activation in inflammatory responses. We therefore tested the effect of angiogenic factors on upregulation of EAM on tumor EC and human… CONTINUE READING