Tumor angiogenesis—new drugs on the block

@article{Brower1999TumorAD,
  title={Tumor angiogenesis—new drugs on the block},
  author={Vicki Brower},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={963-968}
}
  • V. Brower
  • Published 1 October 1999
  • Biology
  • Nature Biotechnology
Angiogenesis inhibitors could represent a powerful adjunct to traditional cancer treatments, but the most effective routes for therapeutic intervention remain unclear. 
Growth inhibition of prostate cancer xenografts by halofuginone * †
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The efficacy of halofuginone to inhibit prostate cancer xenografts representing various phenotypes of the disease is evaluated.
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The rationale forAntiangiogenesis as a treatment strategy, the preclinical and clinical assessment of antiangiogenic interventions, and the various treatment strategies, including combining antiangIogenic drugs with radiation and chemotherapy are discussed.
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The antiangiogenic effects of the majority of currently known synthetic inhibitors are considered in the context of their roles in the main steps of tumor angiogenesis.
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The enhanced endothelial cell proliferation rate in tumor specimens raised the question whether therapeutic effects of chemotherapeutic agents might be at least partially attributed to an inhibition of tumor angiogenesis, and which application schedules are able to exert a strong antiangiogenic effect.
Tumor angiogenesis as a therapeutic target.
Multiple angiogenesis stimulators in a single malignancy: Implications for anti-angiogenic tumour therapy
TLDR
It is shown that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, produces in vivo at least three biologically active angiogenesis stimulators (vascular endothelial growth factor, basic fibroblast growth factor and interleukin-8).
Anti-angiogenic Treatment Strategies for Malignant Brain Tumors
TLDR
Current anti-angiogenic treatment strategies with emphasis on substances already in clinical trials or candidate substances for clinical trials are provided, and the cellular and molecular basis of these substances is reviewed.
Motif mimetic of epsin perturbs tumor growth and metastasis.
TLDR
UPI peptide markedly impaired functional tumor angiogenesis, tumor growth, and metastasis, resulting in a notable increase in survival in tumor-bearing mice and equipped with localized tumor endothelium-specific targeting, provides potential for an effective and alternative cancer therapy.
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Nature America Inc. • http://biotech.nature.com © 1 99 9 N at u re A m er ic a In c
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