Tumor angiogenesis: cause or consequence of cancer?

  title={Tumor angiogenesis: cause or consequence of cancer?},
  author={Ksenya Shchors and Gerard Evan},
  journal={Cancer research},
  volume={67 15},
Both tumors and normal tissues need a blood supply for oxygen, nutrients, and waste removal. However, whereas normal vasculature is hierarchically assembled into efficient networks of arteries, capillaries, and veins, the blood vessels of tumors are a mess-chaotic, leaky, inefficient, and barely making do. Why the difference? Do tumor vessels lack the signals to mature or, instead, is their maturation actively suppressed? What triggers and maintains tumor vasculature? In a recent study using a… CONTINUE READING


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