Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma.

@article{Weidner1992TumorAA,
  title={Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma.},
  author={Noel Weidner and Judah M Folkman and Franco Pozza and Pierantonio Bevilacqua and Elizabeth N. Allred and D Helen Moore and Salvatore Meli and Giampietro Gasparini},
  journal={Journal of the National Cancer Institute},
  year={1992},
  volume={84 24},
  pages={1875-87}
}
BACKGROUND Axillary lymph node status has been the most important prognostic factor in operable breast carcinoma, but it does not fully account for the varied disease outcome. More accurate prognostic indicators would help in selection of patients at high risk for disease recurrence and death who are candidates for systemic adjuvant therapy. Our recent findings indicated that microvessel density (count or grade) in invasive breast carcinoma (a measure of tumor angiogenesis) is associated with… CONTINUE READING
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