Tumor and serum gamma-glutamyl transpeptidase, new prognostic and molecular interpretation of an old biomarker in gastric cancer

  title={Tumor and serum gamma-glutamyl transpeptidase, new prognostic and molecular interpretation of an old biomarker in gastric cancer},
  author={Qinchuan Wang and Xiang Shu and Yong Dong and Jichun Zhou and Rong-yue Teng and Jian-guo Shen and Yongxia Chen and Mingjun Dong and Wenjun Zhang and Yasheng Huang and Shu-duo Xie and Qun Wei and Wenhe Zhao and Wenjun Chen and Xiaoming Yuan and Xuanchang Qi and Linbo Wang},
  pages={36171 - 36184}
Background Gastric Cancer is one of the most lethal malignancies worldwide. Gamma-glutamyl transpeptidase (GGT) is an enzyme mainly involved in cellular glutathione homeostasis. We aim to explore the clinical value of GGT in gastric cancer. Results Among 322 patients enrolled, 65/82 patients were determined as GGT positive in serum/tumor, respectively. High tumor GGT expression is significantly associated with lymph node metastasis, histological subtype, and Her2 expression. Kaplan-Meier curve… 

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