Tumor and Stem Cell Biology RNAi-Mediated Silencing ofMyc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer

@inproceedings{Civenni2013TumorAS,
  title={Tumor and Stem Cell Biology RNAi-Mediated Silencing ofMyc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer},
  author={Gianluca Civenni and Anastasia Malek and Domenico Albino and Ram{\'o}n Garc{\'i}a-Escudero and Sara Napoli and Stefano Di Marco and Sandra Pinton and M. {\'A}ngeles Sarti and Giuseppina Maria Carbone and Carlo Vittorio Catapano},
  year={2013}
}
Several studies link disease progression, recurrence, and treatment failures to the cancer stem-like cell (CSC) subpopulation within the heterogeneous tumor cell population. Myc is a transcription factor having a central function in stem cell biology and in human cancers. Hence, Myc represents an attractive target to develop CSC-specific therapies. Recent findings suggest that Myc transcription can be silenced using an RNA interference (RNAi)–based strategy that targets noncoding promoter… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

MYC on the Path to Cancer

  • Cell
  • 2012
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…