Tumor and Stem Cell Biology D Np 63 Versatilely Regulates a Broad NFk B Gene Program and Promotes Squamous Epithelial Proliferation , Migration , and Inflammation

@inproceedings{Yang2011TumorAS,
  title={Tumor and Stem Cell Biology D Np 63 Versatilely Regulates a Broad NFk B Gene Program and Promotes Squamous Epithelial Proliferation , Migration , and Inflammation},
  author={Xinping Yang and Hai Lu and Bin Yan and Rose-Anne Romano and Yansong Bian and Jay A Friedman and Praveen Duggal and Clint Allen and Ryan Chuang and Reza Ehsanian and Han Si and Satrajit Sinha and Carter Van Waes and Zhong Chen},
  year={2011}
}
Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant nuclear activation of TP53 and NF-kB family members DNp63, cRel, and RelA. However, the mechanisms of cross-talk by which these transcription factors coordinate gene expression and the malignant phenotype remain elusive. In this study, we showed that DNp63 regulates a cohort of genes involved in cell growth, survival… CONTINUE READING
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