Corpus ID: 1048553

Tumor and Stem Cell Biology D Np 63 Versatilely Regulates a Broad NFk B Gene Program and Promotes Squamous Epithelial Proliferation , Migration , and Inflammation

@inproceedings{Yang2011TumorAS,
  title={Tumor and Stem Cell Biology D Np 63 Versatilely Regulates a Broad NFk B Gene Program and Promotes Squamous Epithelial Proliferation , Migration , and Inflammation},
  author={X. Yang and Hai Lu and B. Yan and Rose-Anne Romano and Y. Bian and Jay A Friedman and P. Duggal and C. Allen and R. Chuang and R. Ehsanian and H. Si and S. Sinha and C. Waes and Z. Chen},
  year={2011}
}
  • X. Yang, Hai Lu, +11 authors Z. Chen
  • Published 2011
  • Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant nuclear activation of TP53 and NF-kB family members DNp63, cRel, and RelA. However, the mechanisms of cross-talk by which these transcription factors coordinate gene expression and the malignant phenotype remain elusive. In this study, we showed that DNp63 regulates a cohort of genes involved in cell growth, survival… CONTINUE READING

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