Tumor and Stem Cell Biology Changes in Pyruvate Metabolism Detected by Magnetic Resonance ImagingAre Linked toDNADamage andServe as aSensor of TemozolomideResponse inGlioblastomaCells


Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate. To understand themechanistic basis for this effect and its potential utility as a TMZ response biomarker, we compared the response of isogenic GBM cell populations differing only in expression of… (More)


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