Tumor and Stem Cell Biology Changes in Pyruvate Metabolism Detected by Magnetic Resonance ImagingAre Linked toDNADamage andServe as aSensor of TemozolomideResponse inGlioblastomaCells

Abstract

Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate. To understand themechanistic basis for this effect and its potential utility as a TMZ response biomarker, we compared the response of isogenic GBM cell populations differing only in expression of… (More)

Topics

6 Figures and Tables

Slides referencing similar topics