Tumor and Stem Cell Biology CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation

Abstract

Activation of EGF receptor (EGFR) triggers signaling pathways regulating various cellular events that contribute to tissue development and function. Aberrant activation of EGFR contributes to tumor progression as well as therapeutic resistance in patients with cancer. C-terminal tensin-like (CTEN; TNS4) is a focal adhesion molecule that is a member of the… (More)

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