Tumor and Stem Cell Biology Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFkB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells

Abstract

Acquired chemoresistance has curtailed cancer survival since the dawn of chemotherapy. Accumulating evidence suggests a major role for cancer stem cells (CSC) in chemoresistance, although their involvement in acquired resistance is still unknown. The use of aspirin has been associated with reduced cancer risk and recurrence, suggesting that the anti… (More)

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