Tumor Suppressor Protein p53 Negatively Regulates Human Pregnane X Receptor Activity s


The human pregnane X receptor (PXR) regulates genes involved in drug metabolism and disposition. PXR associates with multiple corepressors that attenuate and coactivators that enhance its activity. PXR plays a vital role in the drugmetabolism pathway, and a comprehensive examination of PXR-associated proteins will provide greater insight into the regulation… (More)


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